Global Label Membrane MPNN
Design protein sequences on fixed backbones using a ProteinMPNN variant globally conditioned to be membrane or soluble. Global Label Membrane MPNN takes PDB backbones (up to 1,024 residues) and generates batches of sequences per structure with a user-specified global_transmembrane_label, preserving fold while matching the desired environment. This is useful for designing membrane-mimetic scaffolds, solubilized analogues of membrane folds, and for comparing membrane vs soluble sequence solutions for the same topology.
