HyperMPNN

HyperMPNN designs thermostable protein variants from single-chain 3D structures by retraining ProteinMPNN on predicted hyperthermophilic proteomes. The API generates sequence designs biased toward hyperthermophilic-like amino acid compositions (enriched hydrophobic core and charged surfaces) while supporting fixed and redesigned residues, homo-oligomer and symmetry constraints, and optional transmembrane region annotations. It returns full-length sequences with per-residue probabilities and confidence scores for structure-guided stability engineering.