Per-Residue Label Membrane MPNN

Design protein sequences for membrane protein backbones using a ProteinMPNN variant trained with per-residue membrane annotations. For each input PDB, the model samples sequences conditioned on position-wise labels for buried transmembrane and interface residues, enabling fine-grained control over solubility and membrane preference at specific sites. Use residue-level labels, bias terms, and fixed/redesigned residue sets to guide mutations for tuning topology, surface polarity, and environment compatibility.