Pro4S Classification

Pro4S Classification predicts protein solubility from amino acid sequence and corresponding 3D structure (PDB or mmCIF) for a specified chain. The model fuses sequence embeddings, structural graphs, and surface descriptors to output a solubility probability in [0, 1] and an optional soluble/insoluble label. This service is suited for screening recombinant constructs, assessing developability, and prioritizing *de novo* protein designs for higher expression success.