TCRBuilder2

TCRBuilder2 predicts 3D T-cell receptor variable-domain structures from paired alpha (A) and beta (B) chain amino acid sequences, returning refined all-atom PDB models. The model is TCR-specific, trained on curated structural datasets, and runs CPU-only with support for batches of up to 8 TCRs and chain lengths up to 2048 residues. The service supports high-throughput TCR structure generation for repertoire analysis, TCR–pMHC interaction studies, and structure-guided TCR engineering.