TCRBuilder2+

TCRBuilder2+ predicts atomic-level 3D structures of paired T-cell receptors from alpha (A) and beta (B) chain amino acid sequences, using updated ImmuneBuilder weights for improved backbone accuracy across CDR and framework regions. The API accepts batches of up to 8 TCRs (sequence length ≤2048 residues per chain) and returns refined PDB structures suitable for downstream analysis. Typical uses include structural characterization of TCR repertoires, TCR–pMHC interaction studies, and immunotherapy design workflows.