TEMPRO 3B

TEMPRO 3B predicts nanobody (sdAb/VHH) melting temperature (Tm, °C) directly from amino acid sequence using protein language model embeddings. The API accepts single-chain protein sequences of 100–160 residues (typical nanobody length) and returns per-sequence Tm estimates suitable for ranking variants, screening libraries, and triaging designs by thermostability. The service is optimized for batched inference (up to 8 sequences per request) and supports high-throughput workflows in therapeutic, diagnostic, and research settings.